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Hiroyuki Nakamura Selected Research

Neutron Capture Therapy

12/2023Development of a Gadolinium-Boron-Conjugated Albumin for MRI-Guided Neutron Capture Therapy.
1/2023Efficient neutron capture therapy of glioblastoma with pteroyl-closo-dodecaborate-conjugated 4-(p-iodophenyl)butyric acid (PBC-IP).
10/2016Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy.
1/2013Development of high boron content liposomes and their promising antitumor effect for neutron capture therapy of cancers.
12/2010[Minimally invasive cytoselective radiation therapy using boron neutron capture reaction].
5/2008[Boron delivery system for neutron capture therapy of cancer].
2/2008[Liposomal boron delivery system for neutron capture therapy].
9/2006Transferrin-loaded nido-carborane liposomes: tumor-targeting boron delivery system for neutron capture therapy.

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Hiroyuki Nakamura Research Topics

Disease

109Neoplasms (Cancer)
04/2024 - 01/2002
24Hypoxia (Hypoxemia)
05/2024 - 06/2009
20Inflammation (Inflammations)
01/2023 - 03/2006
19Neoplasm Metastasis (Metastasis)
07/2020 - 01/2002
17Lung Neoplasms (Lung Cancer)
01/2024 - 05/2002
15Asthma (Bronchial Asthma)
05/2024 - 01/2004
15Fibrosis (Cirrhosis)
02/2024 - 05/2010
12Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2022 - 12/2012
11Alzheimer Disease (Alzheimer's Disease)
01/2023 - 01/2013
10Carcinoma (Carcinomatosis)
11/2020 - 12/2002
9Infections
01/2021 - 07/2002
8Chronic Renal Insufficiency
05/2024 - 01/2018
8Glioma (Gliomas)
09/2023 - 03/2013
8Schizophrenia (Dementia Praecox)
01/2022 - 08/2009
7Type 2 Diabetes Mellitus (MODY)
11/2023 - 08/2014
7Brain Neoplasms (Brain Tumor)
09/2023 - 01/2009
6Hypertension (High Blood Pressure)
05/2024 - 11/2018
6Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
04/2023 - 07/2012
6Glioblastoma (Glioblastoma Multiforme)
01/2023 - 03/2013
6Dementia (Dementias)
01/2023 - 01/2014
6Delirium
01/2023 - 01/2014
6Chronic Obstructive Pulmonary Disease (COPD)
12/2022 - 04/2013
6Melanoma (Melanoma, Malignant)
08/2022 - 03/2002
6Squamous Cell Carcinoma of Head and Neck
11/2020 - 08/2014
6Rheumatoid Arthritis
01/2020 - 09/2009
6Carcinogenesis
12/2018 - 01/2002
5Pulmonary Fibrosis (Fibrosing Alveolitis)
02/2024 - 11/2013
5Stomach Neoplasms (Stomach Cancer)
09/2023 - 02/2008
5Non-alcoholic Fatty Liver Disease
04/2023 - 02/2020
5Ulcerative Colitis
01/2022 - 01/2012
5Colonic Neoplasms (Colon Cancer)
01/2021 - 01/2003
5Hepatocellular Carcinoma (Hepatoma)
01/2009 - 11/2002
4Head and Neck Neoplasms (Head and Neck Cancer)
11/2023 - 01/2009
4Body Weight (Weight, Body)
11/2023 - 09/2006
4Breast Neoplasms (Breast Cancer)
10/2023 - 08/2002
4Tuberculosis (Tuberculoses)
06/2023 - 11/2002
4Lung Injury
04/2023 - 08/2011
4Airway Remodeling
01/2023 - 05/2012
4Chronic Pain
11/2022 - 01/2020
4Pain (Aches)
01/2022 - 01/2010
4Hypersensitivity (Allergy)
11/2021 - 11/2009

Drug/Important Bio-Agent (IBA)

31BoronIBA
12/2023 - 03/2002
29Proteins (Proteins, Gene)FDA Link
02/2024 - 01/2002
13Liposomes (Liposome)IBA
11/2021 - 09/2006
10AlbuminsIBA
12/2023 - 06/2013
10Biomarkers (Surrogate Marker)IBA
11/2023 - 01/2013
101-phenyl-3,3-dimethyltriazene (PDT)IBA
09/2023 - 02/2010
10LipidsIBA
06/2022 - 01/2009
9EnzymesIBA
11/2023 - 01/2004
9Glucose (Dextrose)FDA LinkGeneric
11/2023 - 01/2003
9Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2021 - 06/2009
7Antipsychotic Agents (Antipsychotics)IBA
01/2023 - 08/2009
7CytokinesIBA
09/2022 - 01/2004
7Messenger RNA (mRNA)IBA
08/2022 - 02/2010
7ErbB Receptors (EGF Receptor)IBA
05/2022 - 10/2009
7ProstaglandinsIBA
12/2018 - 01/2009
6Indicators and Reagents (Reagents)IBA
04/2024 - 04/2005
6Therapeutic UsesIBA
12/2023 - 11/2005
6dodecaborateIBA
09/2023 - 02/2012
6CholesterolIBA
04/2023 - 07/2012
6SteroidsIBA
01/2023 - 08/2006
6ceramide kinaseIBA
09/2022 - 01/2010
6VitaminsIBA
05/2022 - 12/2017
6tofacitinibIBA
01/2022 - 08/2011
6Photosensitizing Agents (Photosensitizers)IBA
01/2020 - 07/2012
6Arachidonic Acid (Vitamin F)IBA
01/2015 - 04/2005
5Janus Kinase InhibitorsIBA
03/2024 - 05/2014
5Uric Acid (Urate)IBA
01/2024 - 09/2019
5GlucocorticoidsIBA
01/2023 - 05/2021
5SodiumIBA
06/2022 - 01/2009
5CreatinineIBA
01/2021 - 11/2010
5DNA (Deoxyribonucleic Acid)IBA
10/2020 - 03/2006
5C-Reactive ProteinIBA
02/2020 - 09/2009
5SphingolipidsIBA
01/2020 - 03/2006
5Hyaluronic Acid (Hyaluronan)IBA
11/2018 - 12/2003
5AntibodiesIBA
01/2018 - 01/2002
5Immunoglobulin E (IgE)IBA
01/2016 - 12/2003
5Olanzapine (Zyprexa)FDA Link
09/2014 - 08/2009
5Risperidone (Risperdal Consta)FDA LinkGeneric
09/2014 - 08/2009
4Heat-Shock Proteins (Heat-Shock Protein)IBA
05/2024 - 09/2014
4ceramide glucosyltransferaseIBA
02/2024 - 11/2016
4GadoliniumIBA
12/2023 - 05/2012
4Fatty Acids (Saturated Fatty Acids)IBA
11/2023 - 01/2019
4protoporphyrin IXIBA
09/2023 - 02/2010
4Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
08/2023 - 02/2006
4Bleomycin (Blenoxane)FDA LinkGeneric
04/2023 - 11/2013
4ApolipoproteinsIBA
04/2023 - 01/2017
4CollagenIBA
01/2023 - 01/2014
4Anti-Bacterial Agents (Antibiotics)IBA
08/2022 - 06/2002
4Peptides (Polypeptides)IBA
06/2022 - 09/2017
4Prednisolone (Predate)FDA LinkGeneric
04/2022 - 01/2003
4Epidermal Growth Factor (EGF)IBA
10/2021 - 02/2002
4Insulin (Novolin)FDA Link
05/2021 - 01/2003

Therapy/Procedure

45Therapeutics
03/2024 - 06/2002
20Boron Neutron Capture Therapy
12/2023 - 03/2002
15Drug Therapy (Chemotherapy)
10/2023 - 01/2003
9Photochemotherapy (Photodynamic Therapy)
09/2023 - 02/2010
8Neutron Capture Therapy
12/2023 - 09/2006
5Aftercare (After-Treatment)
06/2023 - 04/2002
4Oral Administration
04/2023 - 08/2002